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1

Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogs

Holden, Hazel M., Tronrud, Dale E., Monzingo, Arthur F., Weaver, Larry H., Matthews, Brian W.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.37 MB

english, 1987

2

Investigation of a Sugar N -formyltransferase from the Plant Pathogen Pantoea ananatis

Hofmeister, Daniel L., Thoden, James B., Holden, Hazel M.

Journal:

Protein Science

Year:

2019

Language:

english

File:

PDF, 2.87 MB

english, 2019

3

Enhanced Degradation of Chemical Warfare Agents through Molecular Engineering of the Phosphotriesterase Active Site

Hill, Craig M., Li, Wen-Shan, Thoden, James B., Holden, Hazel M., Raushel, Frank M.

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

4

Carbamoyl phosphate synthetase: a tunnel runs through it

Hazel M Holden, James B Thoden, Frank M Raushel

Journal:

Current Opinion in Structural Biology

Year:

1998

Language:

english

File:

PDF, 583 KB

english, 1998

5

Carbamoyl Phosphate Synthetase: Caught in the Act of Glutamine Hydrolysis †,‡

Thoden, James B., Miran, Sophie G., Phillips, James C., Howard, Andrew J., Raushel, Frank M., Holden, Hazel M.

Journal:

Year:

1998

Language:

english

File:

PDF, 151 KB

english, 1998

6

Structure of Carbamoyl Phosphate Synthetase: A Journey of 96 Å from Substrate to Product †,‡

Thoden, James B., Holden, Hazel M., Wesenberg, Gary, Raushel, Frank M., Rayment, Ivan

Journal:

Year:

1997

Language:

english

File:

PDF, 1.46 MB

english, 1997

7

The HighâResolution Structure of a UDPâlâRhamnose Synthase from Acanthamoeba polyphaga Mimivirus

Bockhaus, Nicholas J., Ferek, Justin D., Thoden, James B., Holden, Hazel M.

Journal:

Protein Science

Year:

2020

File:

PDF, 2.93 MB

2020

8

The Amidotransferase Family of Enzymes: Molecular Machines for the Production and Delivery of Ammonia †

Raushel, Frank M., Thoden, James B., Holden, Hazel M.

Journal:

Year:

1999

Language:

english

File:

PDF, 223 KB

english, 1999

9

C HANNELING OF S UBSTRATES AND I NTERMEDIATES IN E NZYME -C ATALYZED R EACTIONS

Huang, Xinyi, Holden, Hazel M., Raushel, Frank M.

Journal:

Annual Review of Biochemistry

Year:

2001

Language:

english

File:

PDF, 1.11 MB

english, 2001

10

ChemInform Abstract: The Crotonase Superfamily: Divergently Related Enzymes that Catalyze Different Reactions Involving Acyl Coenzyme A Thioesters

Hazel M. Holden, Matthew M. Benning, Toomas Haller, John A. Gerlt

Journal:

Year:

2001

File:

PDF, 25 KB

2001

11

Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS

Laura Ferraiuolo, Joseph P. De Bono, Paul R. Heath, Hazel Holden, Paul Kasher, Keith M. Channon, Janine Kirby, Pamela J. Shaw

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 359 KB

english, 2009

12

X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 Å resolution

Hazel M. Holden, Masaaki Ito, David J. Hartshorne, Ivan Rayment

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 1.24 MB

english, 1992

13

Molecular Architecture of TylM1 from Streptomyces fradiae : An N , N -Dimethyltransferase Involved in the Production of dTDP- d -mycaminose,

Carney, Amanda E., Holden, Hazel M.

Journal:

Year:

2011

Language:

english

File:

PDF, 5.08 MB

english, 2011

14

Iron-Sulfur Cluster Cysteine-to-Serine Mutants of Anabaena [2Fe-2S] Ferredoxin Exhibit Unexpected Redox Properties and Are Competent in Electron Transfer to Ferredoxin:NADP + Reductase †

Hurley, John K., Weber-Main, Anne M., Hodges, Anne E., Stankovich, Marian T., Benning, Matthew M., Holden, Hazel M., Cheng, Hong, Xia, Bin, Markley, John L., Genzor, Carlos, Gomez-Moreno, Carlos, Hafe

Journal:

Year:

1997

Language:

english

File:

PDF, 624 KB

english, 1997

15

Histidine 90 Function in 4-Chlorobenzoyl-Coenzyme A Dehalogenase Catalysis †,‡

Zhang, Wenhai, Wei, Yansheng, Luo, Lusong, Taylor, Kimberly L., Yang, Guang, Dunaway-Mariano, Debra, Benning, Matthew M., Holden, Hazel M.

Journal:

Year:

2001

Language:

english

File:

PDF, 294 KB

english, 2001

16

Structural and Functional Studies of QdtC: An N -Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-dideoxy-α- d -glucose †‡

Thoden, James B., Cook, Paul D., Schäffer, Christina, Messner, Paul, Holden, Hazel M.

Journal:

Year:

2009

Language:

english

File:

PDF, 5.20 MB

english, 2009

17

Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase

Dopkins, Brandon J., Tipton, Peter A., Thoden, James B., Holden, Hazel M.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.85 MB

english, 2016

18

Structural and Biochemical Investigation of PglF from Campylobacter jejuni Reveals a New Mechanism for a Member of the Short Chain Dehydrogenase/Reductase Superfamily

Riegert, Alexander S., Thoden, James B., Schoenhofen, Ian C., Watson, David C., Young, N. Martin, Tipton, Peter A., Holden, Hazel M.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.25 MB

english, 2017

19

Kinetic mechanism of asparagine synthetase from Vibrio cholerae

Vicente Fresquet, James B Thoden, Hazel M Holden, Frank M Raushel

Journal:

Bioorganic Chemistry

Year:

2004

Language:

english

File:

PDF, 243 KB

english, 2004

20

Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase

Ricardo Martí-Arbona, James B. Thoden, Hazel M. Holden, Frank M. Raushel

Journal:

Bioorganic Chemistry

Year:

2005

Language:

english

File:

PDF, 251 KB

english, 2005

21

Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

Baker, Duncan E C, Harrison, Neil J, Maltby, Edna, Smith, Kath, Moore, Harry D, Shaw, Pamela J, Heath, Paul R, Holden, Hazel, Andrews, Peter W

Journal:

Nature Biotechnology

Year:

2007

Language:

english

File:

PDF, 325 KB

english, 2007

22

Structural and Biochemical Characterization of a Bifunctional Ketoisomerase/ N -Acetyltransferase from Shewanella denitrificans

Chantigian, Daniel P., Thoden, James B., Holden, Hazel M.

Journal:

Year:

2013

Language:

english

File:

PDF, 729 KB

english, 2013

23

Molecular Structure of the Oxidized High-Potential Iron-Sulfur Protein Isolated from Ectothiorhodospira vacuolata

Benning, Matthew M., Meyer, Terrance E., Rayment, Ivan, Holden, Hazel M.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.31 MB

english, 1994

24

Molecular Architectures of Pen and Pal: Key Enzymes Required for CMP-Pseudaminic Acid Biosynthesis in Bacillus thuringiensis

Delvaux, Nathan A., Thoden, James B., Holden, Hazel M.

Journal:

Protein Science

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

25

Kinetic Mechanism of Kanamycin Nucleotidyltransferase from Staphylococcus aureus

Misty Chen-Goodspeed, Janeen L. Vanhooke, Hazel M. Holden, Frank M. Raushel

Journal:

Bioorganic Chemistry

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

26

Structural Analysis of the Active Site Geometry of N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase from Escherichia coli †,‡

Thoden, James B., Holden, Hazel M., Firestine, Steven M.

Journal:

Year:

2008

Language:

english

File:

PDF, 6.73 MB

english, 2008

27

Carbamoyl Phosphate Synthetase: Closure of the B-Domain as a Result of Nucleotide Binding †,‡

Thoden, James B., Wesenberg, Gary, Raushel, Frank M., Holden, Hazel M.

Journal:

Year:

1999

Language:

english

File:

PDF, 399 KB

english, 1999

28

Structural and Functional Studies of WlbA: A Dehydrogenase Involved in the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy- d -mannuronic Acid,

Thoden, James B., Holden, Hazel M.

Journal:

Year:

2010

Language:

english

File:

PDF, 5.38 MB

english, 2010

29

The Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. Strain SU

Song, Feng, Thoden, James B., Zhuang, Zhihao, Latham, John, Trujillo, Michael, Holden, Hazel M., Dunaway-Mariano, Debra

Journal:

Year:

2012

Language:

english

File:

PDF, 1.71 MB

english, 2012

30

Crystal structure of gene locus At3g16990 from Arabidopsis thaliana

Paul G. Blommel, David W. Smith, Craig A. Bingman, David H. Dyer, Ivan Rayment, Hazel M. Holden, Brian G. Fox, George N. Phillips Jr.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2004

Language:

english

File:

PDF, 88 KB

english, 2004

31

The isolation, purification, and preliminary crystallographic characterization of udp-galactose-4-epimerase from Escherichia coli

Alan J. Bauer, Ivan Rayment, Perry A. Frey, Hazel M. Holden

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 762 KB

english, 1991

32

Molecular structure of an apolipoprotein determined at 2.5-.ANG. resolution

Breiter, Deborah R., Kanost, Michael R., Benning, Matthew M., Wesenberg, Gary, Law, John H., Wells, Michael A., Rayment, Ivan, Holden, Hazel M.

Journal:

Year:

1991

Language:

english

File:

PDF, 702 KB

english, 1991

33

Crystallographic Evidence for Tyr 157 Functioning as the Active Site Base in Human UDP−Galactose 4-Epimerase †,‡

Thoden, James B., Wohlers, Travis M., Fridovich-Keil, Judith L., Holden, Hazel M.

Journal:

Year:

2000

Language:

english

File:

PDF, 764 KB

english, 2000

34

GDP-Perosamine Synthase: Structural Analysis and Production of a Novel Trideoxysugar †,‡

Cook, Paul D., Holden, Hazel M.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.50 MB

english, 2008

35

Three-Dimensional Structure of N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase: A Member of the ATP Grasp Protein Superfamily †,‡

Thoden, James B., Kappock, T. Joseph, Stubbe, JoAnne, Holden, Hazel M.

Journal:

Year:

1999

Language:

english

File:

PDF, 834 KB

english, 1999

36

High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol

James B. Thoden, Perry A. Frey, Hazel M. Holden

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 10.61 MB

english, 1996

37

Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1

Schröder, Rasmus R., Manstein, Dietmar J., Jahn, Werner, Holden, Hazel, Rayment, Ivan, Holmes, Kenneth C., Spudich, James A.

Journal:

Year:

1993

File:

PDF, 860 KB

1993

38

Trimethyllead acetate: A first-choice heavy atom derivative for protein crystallography

Hazel M. Holden, Ivan Rayment

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 1.84 MB

english, 1991

39

Three-dimensional structure of the high-potential iron-sulfur protein isolated from the purple phototrophic bacterium Rhodocyclus tenuis determined and refined at 1.5 Å resolution

Ivan Rayment, Gary Wesenberg, Terry E. Meyer, Michael A. Cusanovich, Hazel M. Holden

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 4.07 MB

english, 1992

40

Combined Structural and Functional Investigation of a C-3′′-Ketoreductase Involved in the Biosynthesis of dTDP- l -Digitoxose

Kubiak, Rachel L., Holden, Hazel M.

Journal:

Year:

2011

Language:

english

File:

PDF, 6.46 MB

english, 2011

41

Three-Dimensional Structure of the Biotin Carboxylase Subunit of Acetyl-CoA Carboxylase

Waldrop, Grover L., Rayment, Ivan, Holden, Hazel M.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.41 MB

english, 1994

42

Divergence of Chemical Function in the Alkaline Phosphatase Superfamily: Structure and Mechanism of the P−C Bond Cleaving Enzyme Phosphonoacetate Hydrolase

Kim, Alexander, Benning, Matthew M., OkLee, Sang, Quinn, John, Martin, Brian M., Holden, Hazel M., Dunaway-Mariano, Debra

Journal:

Year:

2011

Language:

english

File:

PDF, 4.85 MB

english, 2011

43

Biochemical and Structural Characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum : Enzymes Required for the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy- d -mannuronic Acid

Thoden, James B., Holden, Hazel M.

Journal:

Year:

2011

Language:

english

File:

PDF, 4.28 MB

english, 2011

44

Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry

Thoden, James B., Vinogradov, Evgeny, Gilbert, Michel, Salinger, Ari J., Holden, Hazel M.

Journal:

Year:

2015

Language:

english

File:

PDF, 8.66 MB

english, 2015

45

Enzymes required for the biosynthesis of N-formylated sugars

Holden, Hazel M, Thoden, James B, Gilbert, Michel

Journal:

Current Opinion in Structural Biology

Year:

2016

Language:

english

File:

PDF, 2.33 MB

english, 2016

46

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

Mansfield, John C., Holden, Hazel, Tarlow, Joanna K., Di Giovine, Francesco S., McDowell, Tarra L., Wilson, Anthony G., Holdsworth, C.Derek, Duff, Gordon W.

Journal:

Gastroenterology

Year:

1994

Language:

english

File:

PDF, 780 KB

english, 1994

47

Production of a Novel N -Monomethylated Dideoxysugar

Thoden, James B., Holden, Hazel M.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.37 MB

english, 2014

48

New Reactions in the Crotonase Superfamily: Structure of Methylmalonyl CoA Decarboxylase from Escherichia coli †,‡

Benning, Matthew M., Haller, Toomas, Gerlt, John A., Holden, Hazel M.

Journal:

Year:

2000

Language:

english

File:

PDF, 855 KB

english, 2000

49

Structure of the Escherichia coli ArnA N -Formyltransferase Domain in Complex with N 5 -formyltetrahydrofolate and UDP-Ara4N

Genthe, Nicholas A., Thoden, James B., Holden, Hazel M.

Journal:

Protein Science

Year:

2016

Language:

english

File:

PDF, 1.22 MB

english, 2016

50

The molecular structure of UDP-galactose 4-epimerase from Escherichia coli determined at 2.5 Å resolution

Alan J. Bauer, Ivan Rayment, Perry A. Frey, Dr. Hazel M. Holden

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 857 KB

english, 1992

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